Yes. Victron DC-DC chargers are fully compatible with modern smart alternators commonly found in newer vehicles. Smart alternators vary their output to improve fuel efficiency, but without a DC-DC charger, this can result in under-charging your auxiliary battery. Victron chargers overcome this by providing stable, regulated charging regardless of alternator type.
Victron Orion XS DC-DC charger models do not require a relay with your smart alternator.